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Synthesis 1979; 1979(9): 666-686
DOI: 10.1055/s-1979-28790
review
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The Utility of Nitroacetic Acid and its Esters in Organic Synthesis

M. T. Shipchandler*
  • *Central Research & Development Division, International Minerals & Chemical Corporation, P.O. Box 207, Terre Haute, Indiana 47808, U.S.A.
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Publication History

Publication Date:
16 September 2002 (online)

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In this review a summary of the syntheses and properties of nitroacetic acid and its esters is given. In addition, their chemical reactivity in the light of their synthetic utility leading to numerous types of nitro compounds, amino acids, and heterocyclic systems is described. 1. Introduction and Historical Background 2. Methods of Preparation 2.1. Nitroacetic Esters 2.2. Nitroacetic Acid 3. Physical and Spectral Properties 4. Chemical Reactivity 4.1. Nitroacetic Esters 4.2. Nitroacetic Acid 5. Synthetic Utility 5.1. Amino Acids 5.2. Nitro Compounds 5.3. Heterocyclic Compounds 5.4. Carbohydrate Derivatives 6. Recent Developments